If upon opening Imatest you get something like this:
Error: Error using load
Unable to read MAT-file C:\ProgramData\Imatest\mcr_cache\5.0\Master\mcrCache9.2\imates0\.matlab\matlabprefs.mat. File might be corrupt.
Some of your MATLAB files have become corrupted. You can solve this by deleting your CTF folder found at C:\ProgramData\Imatest\mcr_cache\5.0\Master\, then try starting Imatest again.
If you continue to have problems please open an issue on the Imatest Help Center.